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Kari I Kivirikko Selected Research

3,4-dehydroproline

12/2004Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

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Kari I Kivirikko Research Topics

Disease

16Hypoxia (Hypoxemia)
04/2016 - 08/2003
2Insulin Resistance
04/2016 - 10/2014
2Obesity
04/2016 - 10/2014
2Inflammation (Inflammations)
04/2016 - 01/2016
2Ischemia
03/2016 - 04/2010
2Fibrosis (Cirrhosis)
01/2016 - 06/2014
1Atherosclerotic Plaque (Atheroma)
04/2016
1Atherosclerosis
04/2016
1Anemia
04/2016
1Weight Gain
04/2016
1Albuminuria
01/2016
1Sclerosis
01/2016
1Polycythemia (Erythrocytosis)
01/2016
1Heart Failure
06/2014
1Hypertrophy
06/2014
1Left Ventricular Dysfunction
06/2014
1Ventricular Remodeling
06/2014
1Infarction (Infarctions)
04/2010
1Neuroblastoma
10/2007
1Urinary Bladder Neoplasms (Bladder Cancer)
05/2007
1Neoplasms (Cancer)
02/2007
1Perinatal Death
11/2002
1Aortic Aneurysm (Aneurysm, Aortic)
11/2002

Drug/Important Bio-Agent (IBA)

9Oxygen (Dioxygen)IBA
01/2016 - 08/2003
5Transcription Factors (Transcription Factor)IBA
12/2011 - 03/2004
4Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
04/2016 - 10/2007
4CollagenIBA
06/2014 - 10/2007
3Peptides (Polypeptides)IBA
12/2007 - 12/2004
2LipidsIBA
04/2016 - 01/2016
2Glucose (Dextrose)FDA LinkGeneric
04/2016 - 10/2014
2Proline (L-Proline)FDA Link
12/2007 - 12/2004
2EnzymesIBA
12/2007 - 03/2004
2disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA
10/2007 - 09/2006
2Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
05/2007 - 11/2002
2Mixed Function Oxygenases (Monooxygenases)IBA
02/2007 - 08/2005
1CopperIBA
04/2016
1FG-4497IBA
04/2016
1CholesterolIBA
04/2016
1AutoantibodiesIBA
04/2016
1oxidized low density lipoproteinIBA
04/2016
1LDL Lipoproteins (beta Lipoproteins)IBA
04/2016
1LDL Receptors (LDL Receptor)IBA
04/2016
1Messenger RNA (mRNA)IBA
03/2016
1Adenosine Diphosphate (ADP)IBA
03/2016
1PhosphofructokinasesIBA
03/2016
1GlycogenIBA
03/2016
1Adenosine Triphosphate (ATP)IBA
03/2016
1ErythropoietinFDA Link
01/2016
1IsoenzymesIBA
10/2014
1Angiotensin IIIBA
06/2014
1Monoclonal AntibodiesIBA
06/2014
1Plasminogen Activators (Plasminogen Activator)IBA
06/2014
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
06/2014
1Connective Tissue Growth FactorIBA
06/2014
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
04/2010
1Small Interfering RNA (siRNA)IBA
10/2007
1Proteins (Proteins, Gene)FDA Link
10/2007
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
05/2007
1Succinate Dehydrogenase (Fumarate Reductase)IBA
02/2007
1FumaratesIBA
02/2007
1Succinic Acid (Succinate)IBA
02/2007
1Azetidinecarboxylic AcidIBA
12/2004
1leucyl-alanineIBA
12/2004
1Hypoxia-Inducible Factor-Proline DioxygenasesIBA
12/2004
13,4-dehydroprolineIBA
12/2004
1Ketoglutaric Acids (Ketoglutaric Acid)IBA
12/2004

Therapy/Procedure

1Therapeutics
10/2014